Thinking of model railroading as a hobby. Once you have track, scenery, etc., how do you keep it from becoming a dusty mess?
First, control the dust. I've found an ionizing dust collector useful. If you don't have a drywalled ceiling you should either install one or install closed-top valences above the layout.
Second, design for cleaning. Anything that might pick up and fly should be either firmly anchored or removable. The open hose of a Shop-Vac (no nozzle) will minimize the tornado when used around scenery. Install a stocking at the first joint to catch little people, loose cargo and such.
Use those, 'Grab the dust,' cloths - gently. A Swiffer pad keeps water looking wet. (It also keeps the computer monitor and TV screen clean.)
Or - just ignore it. Rail facilities aren't exactly pristine unless freshly blanketed with new-fallen snow. The dust may help to tone down the too-bright colors of the models. Don't overclean. Full-scale reality is a long way from perfect. (To me, nothing says, "This is a model," louder than absolute cleanliness.)
Chuck (Modeling hot, dusty Central Japan in September, 1964 - in a Mojave Desert garage)