Enola Yard is a must. It's on 11/15 just opposite Harrisburg. A very short drive to Marysville and you're looking at the Rockville Bridge. Lots of fast food eatemups along Enola Yard.
In WV, exit 13 puts you at a Cracker Barrel, and a little deeper into town is the restored B&O Martinsburg Roundhouse and Amtrak/Marc station. Great spot to watch trains.
Once you cross the VA line, the Winchester & Western parallels 81 into Winchester then towards Gore on 50.
Have a safe trip.
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