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Sure, as long as the load requirement of the engine doesn't exceed the rating of the decoder .... I've seen it done numerous times !!!
Mark.
From the numbers I've seen, most current HO locos are more than happy with most 'n scale' decoders, and those are quite often installed. In N scale non drop in installs you will very often find a 'z scale' decoder.
Take your pick!
These are all at least 1 amp current rating.
Hardwire harness N and Z scale decoders
http://www.digitrax.com/prd_mobdec_dz123.php
http://www.digitrax.com/prd_mobdec_dz143.php
http://www.digitrax.com/prd_mobdec_dn163.php
Plug-n-Play N and Z scale Decoders
http://www.digitrax.com/prd_mobdec_dz123ps.php
http://www.digitrax.com/prd_mobdec_dz143ps.php
http://www.digitrax.com/prd_mobdec_dn143ip.php
Plug-n-Play N scale DecodersMay be used with low current draw HO locomotives.
http://www.digitrax.com/prd_mobdec_dn122k2.php
http://www.digitrax.com/prd_mobdec_dn163a0.php
http://www.digitrax.com/prd_mobdec_dn163a1.php
http://www.digitrax.com/prd_mobdec_dn163i0.php
http://www.digitrax.com/prd_mobdec_dn163i1a.php
http://www.digitrax.com/prd_mobdec_dn163i1b.php
http://www.digitrax.com/prd_mobdec_dn163i1c.php
http://www.digitrax.com/prd_mobdec_dn163k0a.php
http://www.digitrax.com/prd_mobdec_dn163k0b.php
http://www.digitrax.com/prd_mobdec_dn163k0d.php
http://www.digitrax.com/prd_mobdec_dn163k1b.php
http://www.digitrax.com/prd_mobdec_dn163k1c.php
http://www.digitrax.com/prd_mobdec_dn163k2.php
http://www.digitrax.com/prd_mobdec_dn163m0.php
ESU loksound mini is made for N scale. I put such a decoder into my old run Kato NW 2.
Wolfgang