Since you didn't mention scale, I'll give this in units that, if built with laminated 1/4" plywood subroadbed (total 1/2" thickness) and 1/4" roadbed, plus 3/32" rail+tie depth and slightly over 4" 'Mighty Hand of God,' clearance. Single track, curve radius, 34 inches, huge for N scale, not over-generous for HO. With a total rise of 5"/turn, the grade would be 2.35%, uncompensated. The reach-in clearance of 4" can't be reduced much for N scale, since it's based on a 1:1 scale human hand.
I'm running very short trains on much steeper grades in my much tighter helices, so those aren't very good examples of what to expect.
Chuck (Modeling Central Japan in September, 1964)