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You can get away with HO in that space, but it requires some decision making. There really isn't room for a lot of switching AND continuous run AND large modern locos and cars. Pick 2, basically.
The donut lan Byron posted could be adpated to fit, however, it wouldn;t be practical. As he mentioned, it was designed to be accessible from the outside as well as from within the donut hole. Without that outside access, there are turnouts and crossings that could be trouble spots that would be hard to get at trying to reach from the hole. You could eliminate some of the inside sidings to make the hole bigger, allowing reach to the other track, but now you've made it a lot more of just a round and round layout without many switching opportunities.
My old 8x12 donut layout was like that one - 2 sides were agains walls, but the other two sides were eacily accessible, so along the sides against the walls, all track was within easy reach of the hole, on the other two sides, there was track on both sides , so some things you coudl do from in the hole, and others you had to be on the outside.
Another option if continuous run is the one of the three things you cna give up would be a U shaped switching layout. It doesn't take much benchwork width to have the main line and some industry spots on either side of it. On one leg, you could have a detachable staging yard to set up when running trains that can be easily unclipped and stored under the layout, or maybe put it on wheels so it can be wheels into the open area of the U when not in use. If really ambitious, two such removeable sections, one on each end. They don;t need to be attaced for just alittle switching around, but by attaching them, you have a place for trains to go to and come from off the layout.
But I like switching - if there were no other alternatives, either this or have no layout, I would be happy with something like that. Small though ti would be, the switching moves could keep you busy for hours. Especially if you include sidings facing both ways, and one train heads around the layout clockwise and only services trailing point turnouts, and then after that train finishes up, another comes around counter clockwise and handles all the opposite sidings as trailing point moves.
--Randy