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I have extensively used both plywood and MDF in furniture building as well as hardwood lumber. MDF has its advantages and disadvantages. MDF is indeed very heavy, not as strong as plywood (more prone to sagging) and, a very negative point, generally contains considerable amounts of formaldehyde glue which can become a health concern in an airtight home. With barometric changes, MDF releases formaldehyde gas, a known neuro-toxin. Thermofused melamine panels with an MDF core can seal in these gases, particularly when the cut edges are all either banded (Melamine banding) or sealed with shellac or parrafin (paint doesn't seal). All considered, I would recommend that you stick to plywood. I built several plywood RR modules over 30 years ago and they are still in excellent condition today.
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